The Splice Girls are the (fictional) smash all-girl singing group composed of genetically engineered, DNA-spliced monsters from horror movies, like Dren (from Splice), Sil (from Species), Ripley (the genetically modified version from Alien Resurrection), and maybe two others (if they exist). They could sing lots of songs about their feelings of isolation for being the only humanoid monster genetically engineered with spliced DNA, so no-one can relate to them, and they can never find a boyfriend or girlfriend with their interests for destroying humanity and such. Also, they could sing songs about how tempting we are to them, how we are delicious to eat, and how they can walk among us with no-one suspecting they are superhuman monsters thinking about how puny, pathetic and weak we are comparatively.
Their names would be: Scary Splice (Dren), Posh Splice (Sil), and Sporty Splice (Ripley).