I love whodunits, like Agatha Christie stuff, and recently I saw Murder by Death again, and the murder in a house milieu made me think of a fun ad for Lysol. Here's how it would work:
There is the usual collection of people in an English country house (the landed gentry older guy, his younger and conniving second wife, his callow and greedy younger brother, his sweet but mysterious daughter, the sexy maid, the suspicious gardener, the snobby butler: you get the idea), and there is a series of killings in the home, that of the germs. Yes, all the germs have been killed in the kitchen, in the bathrooms: all through the house the germs are dead (!), and the police are called to solve the case. And so a police inspector must solve the mystery of the killed germs, attempting to find the culprit in this Agatha Chtistie-esque collection of characters, and a large can of Lysol, who is also under suspicion. And so the detective finds that the Lysol has killed all the germs, reasoning that it must be the Lysol, since Lysol kills 99.9% of germs; and so rather than take the Lysol to jail, he takes it to his home to do community service of killing all the germs in his house too. And they all live happily ever after, healthy and clean and safe, because Lysol kills 99.9% of bacteria.
(I think this would make a fun play on the usual informational ad with the video of someone spraying Lysol on bathtubs and toilets and such, and it would drive home the idea that Lysol kills 99.9% of germs in a fun and memorable manner, within a milieu we all know and love.)